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KMID : 0387820110180010054
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Clinical Pediatric Hematology-Oncology
2011 Volume.18 No. 1 p.54 ~ p.57
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A Case of Central Retinal Vein Occlusion by Protein C Deficiency
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Kim Beom-Soo
Jeon In-Cheol
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Abstract
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Protein C (PC) is a vitamin K-dependent plasma protein synthesized as a zymogen by liver. It’s active form has an anti-thrombotic activity by cleaving the coagulation factor Va and VIIIa. During the last few years, a large number of cases with protein C deficiency (PCD) which contain variable mutations have been documented. Those with hereditary protein C deficiency tend to have an increased risk of thromboembolism. Hypertension, diabetes, hyperlipidemia and glaucoma are the main underlying diseases of the retinal vein occlusion (RVO). Rarely, thrombophilia (antithrombin III, protein S, protein C deficiency) results in the RVO which usually occurs after adolescent period. We recently experienced a case of central retinal vein occlusion by a PCD.
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KEYWORD
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Protein C, Renal vein occlusion
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